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• Melatonin HALAL Fast Delivery
• 73-31-4 Melatonin for sale
• 73-31-4 Melatonin exporters

Quick Details

• ProName: Melatonin HALAL Fast Delivery 73-31-4 ...
• CasNo: 73-31-4
• Molecular Formula: C13N2H16O2
• Appearance: Off-white crystalline powder
• Application: Used as a supplement for healthcare pr...
• DeliveryTime: Delivery within three days of payment
• PackAge: Aluminum foil bag or Drums
• Port: any port ,China
• ProductionCapacity: 500 Metric Ton/Year
• Purity: Min98.5%
• Storage: Store at room temperature, airtight, a...
• Transportation: Our melatonin meets air and sea identi...
• LimitNum: 1 Kilogram
• Moisture Content: NMT0.3%
• Impurity: NMT0.4%
• 含量: 99%

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Melatonin HALAL Fast Delivery 73-31-4 Melatonin for sale

A hormone secreted by pineal cells

Pineal hormone, also known as melatonin, is a hormone secreted by pineal cells. Its chemical structure is 5-methoxy-N-acetyltryptamine. Its physiological function is to inhibit gonad, thyroid, adrenal gland, parathyroid gland and pituitary gland functions, inhibit children's sexual precocity and reduce pituitary secretion of melanin. And has central nervous system function, can raise convulsive threshold, cause drowsiness and so on.

When the pineal gland was removed, the experimental animals showed hyperplasia and weight increase of all the above-mentioned glands, especially premature gonads and sexual organs of immature rats, increased secretion of LH and FSH from pituitary gland, and increased secretion of thyroid and adrenal cortical hormones. Pineal element can also reduce the pituitary MSH and whiten the skin.

It acts on the central nervous system, showing slow rhythm, increasing convulsion threshold and drowsiness in human electroencephalogram, but does not affect their behavior and personality. It can reduce electroencephalogram changes of motor nervous disorders in people with temporal lobe epilepsy and Parkinson's disease.

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Melatonin HALAL Fast Delivery 73-31-4 Melatonin for sale

Synthesis and release of pineal hormones

Pineal cells absorb tryptophan from blood circulation and convert it into 5-hydroxytryptophan catalyzed by hydroxylase. The latter is decarboxylated to 5-hydroxytryptophan by decarboxylase. There are three possible transformations of 5-hydroxytryptophan: Part of tryptophan is deaminated by monoamine oxidase to 5-hydroxyindole acetic acid; The other leaves pineal cells and is taken up by sympathetic nerve endings and stored with the neurotransmitter noradrenaline. The third part is acetylated by N-acetyl 5-hydroxytryptamine transferase and then O-methoxy by hydroxylated indole-o-methyl transferase to form melatonin. After the synthesis of melatonin, it may be released by cells into the blood circulation or into the blood circulation through the cerebrospinal fluid. Noradrenaline can enhance its synthesis, and its speed depends on the activity of hydroxylase in liver cell microsomes. Under the catalysis of this enzyme, 6-hydroxymelatonin is formed, which is then combined with glucuronic acid and sulfate and excreted through urine.

Physiological role of the pineal gland

① The effect on the brain: the brain intake of melatonin concentrated in the midbrain and hypothalamus, it enhances the activity of brain pyridoxal kinase, thereby promoting the decarboxylation of glutamic acid to form γ-aminobutyric acid, 5-hydroxytryptophan acid decarboxylation to form 5-hydroxytryptophan, the two inhibitory neurotransmitter content increase, the central adjustment and sedative effect.

② Effect on hypothalamus and pituitary gland: In addition to AVT, there are thyroid-stimulating hormone releasing hormone (TRH) and luteinizing hormone releasing hormone (LRH) produced by the pineal gland, which are the same as that produced by the hypothalamus. After melatonin injection, gonadotropin (GNH) (FSH, LH) and melanocytostimulating hormone (MSH) were decreased, while growth hormone (GH) was increased. Pituitary hypertrophy was induced by resection of the pineal gland. The secretion of GNH (FSH, LH) and ACTH increased, while the secretion of prolactin (PRL) and antidiuretic hormone (ADH) decreased.

③ Relationship with gonads: pineal hormone has an inhibitory effect on the reproductive system. Clinically, pineal master cell tumor can lead to delayed puberty, while pineal teratoma can be complicated with precocious puberty due to the exclusion of master cells. Ambient light and sympathetic nerves may affect reproductive system function by controlling melatonin synthesis and release in the pineal gland.

(4) Relationship with thyroid: administration of melatonin reduces thyroid hormone secretion, which may inhibit thyroid function by inhibiting TRH release in hypothalamus and TSH secretion in pituitary gland.

(5) Relationship with the adrenal cortex: melatonin has a strong inhibitory effect on the adrenal cortex. Injecting pineal extract in healthy people can reduce the secretion of aldosterone and the excretion of 17 ketone steroid.

⑥ The relationship with pancreatic islets: pineal hormone can lead to reduced blood sugar, increased glucose tolerance. In conclusion, pine cones can assist pituitary gland to jointly regulate endocrine function, and play an important role in maintaining a relatively constant internal environment of the body and controlling some endocrine functions, especially for gonads.