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Piceatannol in bulk supply CAS 10083-24-6 Piceatannol supplier
use：Antioxidant, with anti-inflammatory, anti-thrombus, anti-cancer, anti-cancer, anti-hyperlipidemia, antibacterial and other activities
Alcoholic properties of Pyramidopsis leucoides
Melting point: 223-227 ° C
Boiling point: 108 ° C / 0.04 mmHg (lit.)
Density: 1.1245 (roughestimate)
The refractive index: 1.5190 (estimate)
Storage condition :2-8°C
Solubility: H2O: 0.5 mg/mL
Appearance: powder
PkA :9.17±0.10(Predicted)
Color: lighttantoyellow
Maximum wavelength: (λ Max):323nm(MeOH)(lit.)
Description: like white crystalline powder, light sensitive
Usage: It is a plant metabolic drug with anti-leukemia activity. Inhibits nonreceptor-activating enzymes, splenic tyrosine kinase and lymphocyte-specific protein tyrosine kinase
China Customs Code: 2907299090 Other polyphenols, phenols. Supervision conditions :AB(customs clearance for inbound goods, customs clearance for outbound goods). VAT rate :17.0%. Tax rebate rate :9.0%. MFN tariff :5.5%. General tariff :30.0%
Founded in July 2013, BLRHBiotech Co., Ltd is located in New Industrial Park, Wancheng District, Hebei Province.
It has a total area of ??46,000 square meters with a total investment of 160 million CNY.
It has more than 150 employees, 30% of whom are developers with a bachelor's degree or higher.
We have a full set of laboratory, pilot production equipment.
Designed according to China's new GMP standards, the facility covers an area of ??30,000 square meters with a complete quality control system.
Covering an area of ??5,000 square meters, the R&D center has a biotechnology laboratory with facilities for enzyme technology, a genetic engineering laboratory, a fermentation pilot laboratory and an extraction and synthesis laboratory.
Since its establishment, the R&D center has completed three industrial products, and is currently researching five products.
Currently, we have partnerships with some famous universities in China.
We mainly research, develop, manufacture and sell amino acids such as 5-hydroxytryptophan and their derivatives, and sodium acetate such as sodium acetate trihydrate or anhydride.
5-Hydroxytryptophan is exported to overseas markets such as Europe and America.
In addition, sodium acetate is mainly sold to the domestic market, and is also exported to Southeast Asia and Europe.
The annual output value of all products exceeds 100 million CNY.
We adhere to "innovative development and green development" in our production, and do our best to provide high-quality products to our customers worldwide at reasonable prices.
Process capability: Exclusive patent for natural fermentation process
After-sales service: Perfect after-sales service products are continuously traceable
Details
Piceatannol, alias 3' -hydroxyresveratrol, CAS number 10083-24-6, is an anti-inflammatory, immunomodulatory, and anti-proliferative agent. It inhibited p56LCK and SYK protein tyrosine kinases, and inhibited NF-κB activation and gene expression of TNF-κB. It is synthesized by converting the cytochrome P4501B1 into resveratrol. So what is its biological activity? How do you do the experiment?
First, we introduce the biological activity of pyruvic alcohol:
1) In vitro activity
In mast cells, peregritol is a potent histamine release inhibitor. It inhibited the proliferation of CAP cells in androgen-dependent or non-dependent manner, and significantly reduced the expression of mTOR and its key effectors, Akt and eIF4EBP-1.
It also effectively inhibited CDPK, MLCK, PKC and PKA (IC50 was 19μM, 12μM, 8μM, 3μM, respectively). Pyracitol selectively inhibited the phosphorylation of STAT3/5 tyrosine induced by IFNα, but did not affect STAT1/2, and selectively inhibited the dephosphorylation of JAK1 and IFNAR1 tyrosine, but did not affect TYK2 and IFNAR2. The apoptosis of Bjabburkitt-like lymphoma cells was effectively induced by pyelitol through activation of caspase-3 and changes in mitochondrial permeability, with ED50 of 25 μm, independent of the CD95/Fas signaling pathway.
Picranitol selectively inhibits SYK in mast cells and thus blocks receptor-mediated downstream cellular responses, including inhibition of 1,4,5-IP3 secretion, synthesis, membrane margin fluctuations, and transport. The inhibitory effect of pyelitol on SYK was about 10 times higher than that of Lyn. The phosphorylation of antigen-stimulated SYK and most other cellular proteins in RBL-2H3 cells was strongly inhibited by leucocitol treatment, but the inhibition was dose-dependent on the phosphorylation of receptor γ or β subtypes.
Picarboxyl inhibited the activation of NF-κB induced by TNF,H2O2,PMA, lipopolysaccharide, Okadasic acid, and ceramide. Picranitol inhibited TNF-induced expression of NF-κB-dependent reporter genes (matrix metalloproteinase-9, cyclinase-2, and cyclinD1) by blocking TNF-induced IκBαof, p65 phosphorylation, p65 nuclear translocation, and IκBα kinase activation, independent of tyrosine kinase. Pyrutaxitol inhibits the activity of the enzyme by directly binding to intracellular phosphatidylinositol kinase in a competitive way through adenosine triphosphate, and its anti-hardening effect is better than resveratrol's anti-atherosclerosis effect.
2) In vivo activity
In the treatment of mice with BALB/c colitis induced by sodium dextran sulfate, oral administration of leucitol significantly improved the destruction of colon structure, significantly reduced the production of inflammatory mediators (such as nitric oxide, prostagland E2, and proinflammatory cytokines), and significantly reduced the activity of MPO in the colonic medullary. In DB/DB mouse models of type 2 diabetes, percedranol inhibits early elevation of blood glucose levels and improves impaired glucose tolerance symptoms in later stages.
How do you do the activity test? Generally speaking, there are three methods as follows:
1) Cell experiments
The cells were exposed to increased concentrations of perezitol. To measure cell proliferation, cells were measured at 72 h using a blood cell counter by trypan blue elimination. After 1 week, the colonies were stained with 1.25% crystal violet and quantified by measuring the absorbance at 595nm.
2) Animal experiments
Animal model: Colitis induced by sodium dextran sulfate (DSS) in Febalb /c mice.
3) Kinase assay
Protein tyrosine kinase assay in vitro: Recombinant SYK was expressed in baculovirus infected ST9 cells. The recombinant SYK activity was determined using angiotensin I peptide as substrate. The enzymatic activity of recombinant SYK was measured by phosphorylation of angiotensin I peptide in the presence of various concentrations of elebinol.
In this paper, we introduce the function of pyrutaxol, and describe its biological activity and experimental method in detail. In summary, Piceatannol is a selective inhibitor of protein tyrosine kinase SYK, which inhibits ICA,L,Ito, IKR, Ca2+ transfer and Na+-Ca2+ exchange in addition to IK1. Its target activity was CaK,3 μm. MLCK, 12 microns; PKC, 8 microns.
China (Mainland)
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