Superiority
CAS 501-36-0 GMP High Purity competitive price Resveratrol
Established in July 2013, BLRH Biotech Co.,Ltd is located in new industrial park, Mancheng District, Baoding City, Hebei Province. It covers a total area of more than 46,000 square meters with total investment of CNY 160 million. It has over 150 employees, 30% of them are developers with Bachelor degrees or above. Our company has full set of lab scale, pilot scale and production facilities. The plant ,which is designed according to China New GMP standard, covers an area of 30,000 square meters with perfect quality management system. With an area of 5,000 square meters, R&D center has well-equipped biotechnology-related Enzyme engineering laboratory, Genetic engineering laboratory, Fermentation pilot scale laboratory, Extraction and Synthesis laboratories. Since the establishment of the company, R&D center has finished 3 industrial products and 5 products are under research, meanwhile established cooperative relations with several well-known universities in China. Our company is mainly engaged in research, development, production and marketing of amino acids and its derivatives such as 5-hydroxytryptophan and sodium acetates such as sodium acetate trihydrate and anhydrous. 5-hydroxytryptophan is all exported to overseas market such as Europe and America. And sodium acetates are mainly sold to domestic market also export to Southeast Asia and Europe etc . The annual output value of all products has exceeded CNY 100 million. Our company consistently adheres to “innovation development and green development” during production and dedicates to provide high quality products with reasonable price to global customers.
Process Capability : Exclusive patent for natural fermentation process
After-sale Service : Pefect after sales service Products are permanently traceable
[Pharmacological action]
Resveratrol is not only a chemoprevention agent for tumor diseases, but also a chemoprevention agent for reducing platelet aggregation, preventing and treating atherosclerosis and cardiovascular and cerebrovascular diseases. In the 1990 s, China's science and technology workers of resveratrol studies have advanced, and reveal its pharmacological effects: inhibit platelet condensed with regard to the prevention of myocardial forcedly, cerebral embolism, of anoxic cardiac protection, to burn or uncontrolled hemorrhagic shock caused by cardiac output fell by effective recovery, and can expand arteries and improve microcirculation.
In 1998, American Al Mindell compiled the anti-aging bible, listing resveratrol as one of the "100 most popular effective anti-aging substances". The research and development of resveratrol in peanuts will be one of the most important nutrition topics in the 21st century, said Professor Mao Wenyue, a researcher at the Peanut Research Institute of the Chinese Academy of Agricultural Sciences and a national famous medical expert. So far, NASA has designated peanut as space food. Eating peanut products regularly can alleviate cardiovascular disease, reduce blood fat and delay aging. Foods rich in resveratrol, such as peanut oil and peanut butter, will become the new nutrition and health fashion in the 21st century. Resveratrol is not only a chemoprevention agent for tumor diseases, but also a chemoprevention agent for reducing platelet aggregation, preventing and treating atherosclerosis and cardiovascular and cerebrovascular diseases. Resveratrol had inhibitory effect on Staphylococcus aureus, Cattacoccus, Escherichia coli, Pseudomonas aeruginosa, and had strong inhibitory effect on orphan virus, herpes simplex virus, enterovirus, coxsackie group A and B.
In the 1990 s, China's science and technology workers of resveratrol studies have advanced, and reveal its pharmacological effects: inhibit platelet condensed with regard to the prevention of myocardial forcedly, cerebral embolism, of anoxic cardiac protection, to burn or uncontrolled hemorrhagic shock caused by cardiac output fell by effective recovery, and can expand arteries and improve microcirculation.
Resveratrol is a kind of free radical, antioxidant, related functions are as follows:
1, delay aging;
2, prevent the oxidation of low density lipoprotein, with the potential prevention and treatment of cardiovascular diseases (atherosclerosis and coronary heart disease, ischemic heart disease, hyperlipidemia, etc.);
3. Affect lipid and arachidonic acid metabolism;
4. Anti-thrombosis and anti-platelet aggregation;
5. Anti-inflammatory and anti-allergic effects.
Details
[Synthetic method of resveratrol]
Resveratrol is an inhibitor of oxidative metabolites of many aromatic carcinogens, and is rated as a natural chemoprophylaxis for heart and cerebrovascular diseases and cancer. A large number of studies have shown that resveratrol also has the functions of anti-mutation activity, protecting the cell toxicity induced by oxidized lipoprotein, and inhibiting the proliferation of tumor cells.
Resveratrol was first isolated from the root of Veratrum grandiflorum in 1940. At present, it has been found in at least 72 plants belonging to 31 genera and 21 families, such as Grape and Vitis in the grape family, Arachis, Cassia, Sophora in the leguminous family, Polygonum in the Polygonum family, etc. Because of the low content of resveratrol in plants and the high extraction cost, chemical, biological and genetic engineering methods to prepare resveratrol have become an indispensable means in the process of its development.
[solubility]
Resveratrol is a kind of antioxidant naturally occurring in grape and red wine, mulberry, peanut and Polygonum kepticum. It belongs to polyphenols, soluble in organic solvents, but insoluble in water. The order of dissolution in organic solvents is: acetone > ethanol BBB>thanol BBB2 e> acetate BBB3 ethe>B4 chlorof>.
[Toxic Activity]
Hormonal and genotoxic activity of resveratrol: Cytotoxicity, micronucleus, and metaphase chromosomal translocation of resveratrol were observed in lymphoma of L5178Y mice. Induction of micronuclei was also observed in Chinese hamster V79 cells. The centromere signal and cell cycle analysis of the micronucleus suggest that resveratrol does not directly interfere with the tubulin polymerization released by mitotic cells.
The mechanism of protecting mitochondrial function: some scholars studied the separation of mitochondria from rat brain tissue through the rat model of hypoxic-reoxygenation, and found that resveratrol completely blocked the release of cytochrome C in a concentration-dependent way and significantly reduced the generation of oxide anions at the concentration of 1nmol. The mitochondrial protective membrane damage caused by hypoxia-reoxygenation was protected by about 70% at 0.1 micromol of resveratrol. In the presence of NADH and cytochrome C, a low half effective concentration of 18.34 PM resveratrol blocked mitochondrial oxygen consumption.
Resveratrol protecting mitochondrial function of the three mechanisms: antioxidant properties, complex Ⅲ role and the function of cell membrane stability.
Periodic antipain effect: Verified by 1% formalin test, the results showed that resveratrol opened large and small conductance Ca2+ activated potassium channels, but not ATP-sensitive K+ channels, thus producing an antipain effect in the experiment, proving that resveratrol's antipain effect is related to K+ channels. Voltage dependent K+ channels may also be involved.
China (Mainland)
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